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Nucleic Acids Research, 1975, Vol. 2, No. 3 405-422
© 1975

Articles

A model for chromarin sub-structure incorporating symmetry considerations of histone oligomers

J.E. Hyde and I.O. Walker

Department of Biochemistry, University of Oxford South Parks Road, Oxford OX1 3QU, UK

Received February 5, 1975. Symmetry considerations of the kind of structures which can be generated when dimers of histones f2a1-f3 and f2a2-f2b interact lead to the following conclusions: chromatin subunits based on closedshell structures give rise to discrete, non-interacting nucleoprotein subunits with the histones arranged at random along the DNA chain; open structures based on infinite helices give rise to highly ordered, regular arrangements of dimers. A model is proposed in which helical polymers of f2a1-f3 and f2b-f2a2 form a central core with the DNA helically arranged around it. The helical repeat contains 9.6 turns of B-form DNA and one molecule each of f2a1, f2a2, f2b, f3 and f1. The pitch of the helix is 53Å and the outer diameter 130Å. The protein molecular repeat is 106Å.


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