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Nucleic Acids Research, 1975, Vol. 2, No. 5 625-634
© 1975

Articles

The base-pairing specificity of cellulose-pdT9*

Shirley Gillam, Kimberley Waterman and Michael Smith**

Department of Biochemistry, Faculty of Medicine, University of British Columbia Vancouver, British Columbia V6T 1W5, Canada

Received January 10, 1975.

The stability of the interaction of oligoadenylates, containing single nucleotide substitutions, with cellulose-pdT9 has been studied by thermal elution. In the case of oligodeoxyriboadenylates, the replacement of an internal dA by dC, dG or dT caused destabilization. In the case of oligoriboadenylates, replacement of an internal A residue by C or U resulted in a similar destabilization. However, replacement of an internal A residue by G resulted in a significantly lesser destabilization. The results indicate that caution should be exercised in extrapolation of data on the specificity of deoxyribopolynucleotide-deoxyribopolynucleotide hybridization to-structure of the type deoxyribopolynucleotide-ribopolynucleotide.

*This research was supported by the Medical Research Coucil of Canada

**Medical Research Associate of the Medical Research Coucil of Canada


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