Skip Navigation

This Article
Right arrow Print PDF (445K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Grozdanovic, J.
Right arrow Articles by Hradec, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grozdanovic, J.
Right arrow Articles by Hradec, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1975, Vol. 2, No. 6 821-830
© 1975

Articles

Ribosome-dependent conversion of polyA-containing heterogenous nuclear RNA into smaller RNA molecules

Jan Grozdanovic and Jan Hradec

Department of Biochemistry, Oncological Institute 180 00 Prague, Czechoslovakia

Received March 21, 1975. The polyA-containing heterogenous nuclear RNA fraction separated from total rat liver nRNA by gel filtration on Sepharose 4B followed by affinity chromatography on polyU- Sepharose and containing predominantly the 45S components becomes enzymatically bound to homologous 80S ribosomes and polyribosomes at 0 C. If 80S ribosomes or polyribosomes with bound polyA-containing HnRNA are subjected to a further incubation at 37°C, the original 45S RNA is gradually converted into smaller RNA species of 10– 35S which remain bound to the particle. This ribosome-dependent cleavage of larger HnRNA species into smaller RNA molecules may represent the ultimate step of mRNA maturation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 RNAHome page
A. BARRERA and T. PAN
Interaction of the Bacillus subtilis RNase P with the 30S ribosomal subunit
RNA, March 1, 2004; 10(3): 482 - 492.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.