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Nucleic Acids Research, 1975, Vol. 2, No. 6 873-888
© 1975

Articles

Nucleoside conformations. 19. Temperature and pH effects on the conformation of guanosine phosphates°

Tran-Dinh Son and Wilhelm Guschibauer

Service de Biochimie, Departement de Biologie, Centre d'Etudes Nucléalres de Saclay B.P. N° 2, F-91190 Glf-sur-Yvette, France

Received April 9, 1975. Proton magnetic resonance spectra at 250 MHz were measured as a function of temperature and pH of the three guanosine phosphates. From these data and previously published work the conformational parameters of these compounds were determined. The phosphate group of Guo-5'-P changes its conformation around the C-O bond and its rotation is relatively slow at 20° At neutral pD the S conformation is favoured and tha N form at acid pD. This conformational change is paralleled by a change in exocyclic rotamer distribution and takes place at the pK of the protonation of the base on N7. Although correlation appears to exist between the various conformations, notable exceptions exist.


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