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Nucleic Acids Research, 1975, Vol. 2, No. 6 961-970
© 1975

Articles

Metal ion-mediated specific interactions between nucleic add bases of polynucleotides and amino acid side chains of polypeptides.

Claude Helene

Centre de Biophysique Moléculaire 45045 Orléans Cédex, France

Received April 29, 1975. Interactions between copolypeptides containing Glu and Tyr residues and polynucleotides can be mediated through divalent metal ions such as Zn2+ and Cu2+. Circular dichroism studies show that the binding of metal ion – polypeptide complexes to poly(A) induces an unstacking of adenine bases. Fluorescence investigations demonstrate that Tyrosine – Adenine interactions result from the formation of ternary complexes polypeptide-Zn2+ -polynucleotide.


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