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Nucleic Acids Research, 1975, Vol. 2, No. 7 1123-1128
© 1975

Articles

Formation of internucleotide 3'-5' phosphoramidate links by direct coupling of phosphoryl and amino groups

Geoffrey L. Greene and Robert L. Letsinger

Department of Chemistry, Northwestern University Evanston, Illinois 60201, USA

Received May 16, 1975. The stepwise synthesis of oligomers derived from 5'-amino-5'-deoxythymidine 3'-phosphate and 5'-amino-5'-deoxy-3'-O-mono-P-methoxytritylthymidine is described. The internucleotide phosphoramidate links were formed by condensation of nucleoside 3'-phosphates with aminonucleosides by means of triphenylphosphine and dipyridyl disulfide.


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