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Nucleic Acids Research, 1975, Vol. 2, No. 7 1143-1152
© 1975

Articles

The metabolism of N4-hydroxycytidine – a mutagen for Salmonella typhimurium

Ewa Popowska and Celina Janion

Institute of Biochemistry and Biophysics, Polish Academy of Sciences 02-532 Warsaw Rakowiecka 36, Poland

Received May 19, 1975. Salmonella typhimurium cells were grown in the presence of [14C]-N4-hydroxycytidine (N4OHcyd), a mutagenic nucleoside, and labelling in DNA and RNA digest was traced. The results show that this analogue is incorporated into RNA at a level of 40 µg/100 mg, and into DNA with a yield at least 100-times smaller. Some N4OHcyd was rapidly metabolized and labelling was found in all ribo- and deoxyribo-nucleosides.


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