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Nucleic Acids Research, 1975, Vol. 2, No. 7 1213-1222
© 1975

Articles

Non-Random Frequencies of Short Oligonucleotide Sequences within Poliomyelitis and Encephalomyocarditis Virus RNAs

D.G. Hughes and B.E.H. Maden

Department of Biochemistry, University of Glasgow Glasgow, G12 8QQ, U.K.

Received June 3, 1975. In poliomyelitis and encephalomyocarditis virus RNAs the relative frequencies of several short oligonucleotide sequences differ substantially from those expected on a random basis. The frequencies of CpGp-containing sequences are low, and the frequency of GpUpApGp is considerably lower than that of GpApUpGp. The relationship of these findings to those obtained from host cell RNAs is discussed.


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