Skip Navigation

This Article
Right arrow Print PDF (593K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Li, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, H. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1975, Vol. 2, No. 8 1275-1290
© 1975

Articles

A model for chromatin structure*

Hsueh Jei Li

Department of Chemistry, Brooklyn College of the City University of New York Brooklyn, N.Y. 11210, U.S.A.

Received May 15, 1975.

A model for chromatin structure is presented. (a) Each of four histone species, H2A (IIb1 or f2a2), H2B (IIb2 or f2b), H3 (III or f3) and H4 (IV or f2a1) can form a parallel dimer. (b) These dimers can form two tetramers, (H2A)2(H2b)2 and (H3)2(H4). (c) These two tetramers bind a segment of DNA and condense it Into a "C" segment. (d) The adjacent segments, termed extended or "E" segments, are bound by hlstone H1 (I or fl) for the major fraction of chromatin; the other "E" regions can be either bound by non-histone proteins or free of protein binding. (e) The binding of histones causes a structural distortion of the DNA which, depending upon the external conditions, may generate the formation of either an open structure with a heterogeneous and non-uniform supercoil or a compact structure with a string of beads. The model is supported by experimental data on histone-histone Interaction, histone-DNA Interaction and histone subunit-DNA Interaction.

*This model was presented at the 1975 Meeting of Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, U.S.A. and International Workshop on ‘Model Systems in Protein-Nucleic Acid Interactions’, April 28 - May 1, 1975, Sitges (Barcelona), Spain.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ScienceHome page
H Weintraub and M Groudine
Chromosomal subunits in active genes have an altered conformation
Science, September 3, 1976; 193(4256): 848 - 856.
[Abstract] [PDF]

Home page
 ScienceHome page
C. Hanson, C. Shen, and J. Hearst
Cross-linking of DNA in situ as a probe for chromatin structure
Science, July 2, 1976; 193(4247): 62 - 64.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.