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Nucleic Acids Research, 1975, Vol. 2, No. 8 1321-1328
© 1975

Articles

Rat hepatoma cells nucleolar DNA. II. A possible model of nucleolar DNA organisation

F. Amalric and J.P. Zalta

Centre de Recherches de Biochimie et de Génétique Cellulaires 118 Route de Narbonne, 31077 Toulouse-Cedex, France

Received June 10, 1975. A model of nucleolar DNA organization has been established. Three clearly defined main components are found in ascites hepatoma cell nucleolar DNA by CsCl gradient analysis. A linear arrangement for nucleolar DNA and a model of DNA organization in the neighbourhood of a set of ribosomal genes, which may play a fundamental role in the elaboration of nucleolar chromatin tertiary structure, are presented.


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