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Nucleic Acids Research, 1975, Vol. 2, No. 9 1539-1550
© 1975

Articles

Polynucleotides. XXXII.1 Further studies on the synthesis of oligonucleotides containing 8, 2' -S-cycloadenosine

Morio Ikehara and Tom Tezuka

Faculty of Pharmaceutical Sciences, Osaka University Suita, Osaka, Japan

Received June 30, 1975. A dinucleoside monophosphate, 8, 2'-anhydro-8-mercapto-9-ß-D-arabinofuranosyladenine phosphoryl-(3'-5')-inosine (As pI) was synthesized by the condensation of protected 8-mercaptoadenosine 2', 3'-cyclic phosphate and 2', 3'-isopropylideneinosine with diphenylphosphorochloridate. 8-Mercaptoadenosine 2', 3'-cyclic phosphate was polymerized by using tetraphenylpyrophosphate as the condensing reagent. As oligonucleotides, thus obtained, contained some uncyclized 8-mercaptoadenosineresidues and were cleaved at these sites with 0.3N KOH. As5'-phosphate was synthesized and polymerized with DCC to give oligonucleotides with chain lengths 2 to 9.


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