Nucleic Acids Research, 1992, Vol. 20, No. 10 2453-2458
© 1992
MOLECULAR BIOLOGY |
The C terminus of the NF-
B p50 precursor and an IB isoform contain transcription activation domains
Department of Biology, Boston University 2 Cummington Street, Boston, MA 02215, USA
* To whom correspondence should be addressed
Received February 28, 1992. Revised April 14, 1992. Accepted April 14, 1992.
The p50 subunit of the NF-
B transcription complex is derived from the N-terminal half of a larger precursor protein, p105. Although a fair amount is known about functions located within the p50 sequences, less is known about the C-terminal half of p105. In this report, we have identified a potent transcription activation domain located in the C terminus of mouse p105. In addition, the IBß proteins chicken p40 and human MAD-3, proteins that are related to the p105 C terminus, strongly activated transcription in chicken cells and yeast when fused to GAL4 DNA-binding sequences. Furthermore, chicken p40 is primarily located in the nucleus of chicken cells when overexpressed from a retroviral vector. Our results suggest novel models for the function and regulation of NF-B transcription complexes.
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