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Nucleic Acids Research, 1992, Vol. 20, No. 10 2553-2557
© 1992

MOLECULAR BIOLOGY

Analysis of nonuniformity in intron phase distribution

Alexey Fedorov, Gennadiy Suboch, Maxim Bujakov and Larisa Fedorova

Department of Molecular Basis of Human Genetics and Department of Research of Biopolymer Function and Structure, Institute of Molecular Genetics, Academy of Sciences of Russia Moscow 123182, Russia

Received January 6, 1992. Accepted April 21, 1992.

The distribution of different intron groups with respect to phases has been analyzed. It has been established that group II introns and nuclear introns have a minimum frequency of phase 2 introns. Since the phase of introns is an extremely conservative measure the observed minimum reflects evolutionary processes. A sample of all known, group I introns was too small to provide a valid characteristic of their phase distribution. The findings observed for the unequal distribution of phases cannot be explained solely on the basis of the mobile properties of introns. One of the most likely explanations for this nonuniformity in the intron phase distribution is the process of exon shuffling. It is proposed that group II introns originated at the early stages of evolution and were involved in the process of exon shuffling.


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