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Nucleic Acids Research, 1992, Vol. 20, No. 11 2699-2703
© 1992

MOLECULAR BIOLOGY

Serum, AP-1 and Ets-1 stimulate the human ets-1 promoter

Marie-Ange Majérus, Frédéric Bibollet-Ruche1, Jean-Baptiste Telliez, Bohdan Wasylyk1 and Bernard Bailleul*

Unité 124 INSERM, Institut de Recherches sur le Cancer de Lille, 1 place de Verdun, 59045 Lille Cedex 1LGME CNRS, U 184 INSERM, Institut de Chimie Biologique, Faculté de Médecine, 11 rue Humann, 67085 Strasbourg Cedex, France

*To whom correspondence should be addressed

Received March 23, 1992. Revised May 14, 1992. Accepted May 14, 1992.

The ets-1 proto-oncogene codes for a transcription factor. In order to understand how ets-1 is regulated, we have cloned its promoter. We show that the promoter is inducible by serum and expression of c-Fos and c-Jun, and it is positively auto-regulated by its gene product. A 50 base-pair sequence is sufficient to confer c-Fos + c-Jun and c-Ets-1 responsiveness to a heterologous promoter. This element contains two AP1 and one Ets-1 like motifs. Striking, AP-1 and Ets-1 motifs are found in oncogene responsive units (ORU's) of other promoters, suggesting that combining these motifs is a common mechanism for generating mitogen responsive transcription elements.


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