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Nucleic Acids Research, 1992, Vol. 20, No. 11 2767-2772
© 1992

MOLECULAR BIOLOGY

Heterologous activation of the actinorhodin biosynthetic pathway in Streptomyces lividans

Natalia M. Romero, Victor Parro, Francisco Malpartida1 and Rafael P. Mellado*

Centro Nacional de Biotecnología and Centro de Biologia Molecular, Facultad de Ciencias UAM, Cantoblanco, 28049 Madrid 1Centro Nacional de Biotecnologia and Departamento de Bioquímica, Facultad de Medicina, UAM, Arzobispo Morcillo 4, 28029 Madrid, Spain

*To whom correspondence should be addressed

Received February 21, 1992. Revised April 27, 1992. Accepted April 27, 1992.

A DNA fragment of Streptomyces fradiae is able to activate the antibiotic actinorhodin biosynthetic pathway when cloned in Streptomyces lividans. The activator DNA region has been sequenced and Its transcription initiation and termination sites accurately mapped in vivo. This DNA encodes a 132 nucleotides long transcript which is apparently responsible for the actinorhodin production phenotype, possibly acting as an antisense RNA. The sequence of the activator gene revealed no homology with any other known Streptomyces coelicolor genes concerned with actinorhodin biosynthesis or its pleiotropic regulation.


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