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Nucleic Acids Research, 1992, Vol. 20, No. 12 3051-3056
© 1992

MOLECULAR BIOLOGY

A sequence element associated with the Plasmodium falciparum KAHRP gene is the site of developmentally regulated protein-DNA interactions

Michael Lanzer, Derik de Bruin and Jeffrey V. Ravetch*

DeWitt Wallace Research Laboratory, Division of Molecular Biology, Sloan-Kettering Institute 1275 York Avenue, New York, NY 10021, USA

* To whom correspondence should be addressed

Received March 16, 1992. Revised May 6, 1992. Accepted May 6, 1992.

The Plasmodium falciparum gene encoding the knob associated histidine-rich protein (KAHRP) is shown to be transcriptionally regulated during its expression in the intraerythrocytic cycle as demonstrated by stage specific nuclear run-on analysis. The genomic organization of the KAHRP gene was determined and the structural basis for the stage specific transcription investigated. A sequence motif with two-fold symmetry was found 160 bp upstream of the RNA initiation site. This sequence element interacts with parasite derived nuclear extracts in a stage specific manner that correlates with the transcriptional activity of the KAHRP gene. These studies suggest a functional role for this structural element in the developmental regulation of a P. falciparum erythrocytic gene.


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