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Nucleic Acids Research, 1992, Vol. 20, No. 14 3731-3736
© 1992

GENOME STRUCTURE AND MAPPING

Structural organization and diversification of Y-linked sequences comprising Su(Ste) genes in Drosophila melanogaster

M. D. Balakireva, Yu. Ya. Shevelyov, D. I. Nurminsky, K. J. Livak1,* and V.A. Gvozdev

Institute of Molecular Genetics Kurchatov Square, 123182, Moscow, Russia 1The Du Pont Merck Pharmaceutical Co., Experimental Station PO Box 80328, Wilmington, DE 19880–0328, USA

*To whom correspondence should be addressed

Received March 9, 1992. Revised June 12, 1992. Accepted June 12, 1992.

Expression of the X-linked repeated Stellate (Ste) genes, which code for a protein with 38% similarity to the ß-subunit of casein klnase II, is suppressed by the Su(Ste) locus on the Y chromosome. The structure and evolution of the Y-linked repeats in the region of the Su(Ste) locus were studied. The 2800 bp repeats consist of three main elements: the region of homology to the Ste genes, an adjacent AT-rich, Y-speclfic segment, and mobile element 1360 inserted in the ste sequence. Amplification of repeats was followed by point mutations, deletions, and insertions of mobile elements. DNA sequencing shows that these repeats may be considered as ste pseudogenes or as damaged variants of a putative gene(s) encoding a protein quite different from the ste protein as a result of an alternative splicing pattern. A comparison of 5 variants of the Su(Ste) repeats shows a number of recombination events between amplified and diverged sequences that could be due to either multiple unequal mitotic sister-chromatid exchanges or to gene conversion. It is a first demonstration on a molecular level of these processes occurring in heterochromatic non-rDNA tandemly organized sequences in an eukaryotic genome.


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