Skip Navigation

This Article
Right arrow Print PDF (504K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Bach, I.
Right arrow Articles by Yaniv, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bach, I.
Right arrow Articles by Yaniv, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1992, Vol. 20, No. 16 4199-4204
© 1992

MOLECULAR BIOLOGY

Structure of the gene enconding hepatocyte nuclear factor 1 (HNF1)

Ingolf Bach, Marco Pontoglio and Moshe Yaniv*

Unité des Virus Oncogénes, UA 1149 du CNRS, Départment des Biotechnologies, Institut Pasteur 25 rue de Dr Roux, 75724 Paris cedex 15, France

*To whom correspondence should be addressed

Received May 28, 1992. Revised July 16, 1992. Accepted July 16, 1992.

Genomlc clones have been isolated that cover the entire gene for the transcription factor HNF1 (hepatocyte nuclear factor 1). This protein governs the expression of many genes, synthesized in the liver In a tissue-specific manner. We have determined the intron/exon structure of the HNF1 gene, which is strictly conserved between rat and mouse and estimate that it spans not more than 40kb in the rat genome. Whereas most homeoproteln genes do not contain introns within the homeodomain, HNF1 displays an intron between the regions encoding the second and the third helices. We discuss possible evolutionary mechanisms leading to this homeobox intron/exon pattern.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Diabetes CareHome page
T. Klupa, J. H. Warram, A. Antonellis, M. Pezzolesi, M. Nam, M. T. Malecki, A. Doria, S. S. Rich, and A. S. Krolewski
Determinants of the Development of Diabetes (Maturity-Onset Diabetes of the Young-3) in Carriers of HNF-1{alpha} Mutations: Evidence for parent-of-origin effect
Diabetes Care, December 1, 2002; 25(12): 2292 - 2301.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. G. Tralhao, J. Roudier, S. Morosan, C. Giannini, H. Tu, C. Goulenok, F. Carnot, F. Zavala, V. Joulin, D. Kremsdorf, et al.
Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis
PNAS, May 14, 2002; 99(10): 6991 - 6996.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Li, Z. Xu, Y. Zheng, D. L. Johnson, and J.-h. Ou
Regulation of Hepatocyte Nuclear Factor 1 Activity by Wild-Type and Mutant Hepatitis B Virus X Proteins
J. Virol., May 13, 2002; 76(12): 5875 - 5881.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J A Epstein, T Glaser, J Cai, L Jepeal, D S Walton, and R L Maas
Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.
Genes & Dev., September 1, 1994; 8(17): 2022 - 2034.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.