Skip Navigation

This Article
Right arrow Print PDF (1295K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Rutberg, S. E.
Right arrow Articles by Ronai, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rutberg, S. E.
Right arrow Articles by Ronai, Z.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1992, Vol. 20, No. 16 4305-4310
© 1992

MOLECULAR BIOLOGY

Functional role of the ultraviolet light responsive element (URE; TGACAACA) in the transcription and replication of polyoma DNA

Susan E. Rutberg, Yang M. Yang and Zeev Ronai*

Molecular Carcinogenesis Program, Naylor Dana Institute, American Health Foundation 1 Dana Road, Valhalla, NY 10595, USA

*To Whom Correspondence should be addressed

Received April 16, 1992. Revised May 15, 1992. We have previously Identified a novel 8 bp sequence (UV-responsive element, URE: TGACAACA) present in the regulatory region of polyoma DNA that Interacts with protein factors induced in rat fibroblast cells by exposure to UV light. In the present study, we demonstrate through competitive binding assays that this sequence Is distinct from the partially homologous AP1 and CRE target sequences. The proteins that bind to the URE appear to have transcriptional activity in UVexposed rat flbroblasts. In addition, the URE appears to play a role in promoting the replication of polyoma DNA as determined through two different experimental approaches. Together, these findings suggest that the URE is a novel DNA binding element that interacts with proteins involved in the transcription and replication of polyoma sequences.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cell Growth Differ.Home page
Y.-M. Yang, W. C. Hatch, Z.-Y. Liu, B. Du, and J. E. Groopman
{beta}-Chemokine Induction of Activation Protein-1 and Cyclic AMP Responsive Element Activation in Human Myeloid Cells
Cell Growth Differ., April 1, 2001; 12(4): 211 - 221.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. T. Kays and J. Piatigorsky
Aldehyde dehydrogenase class 3 expression: Identification of a cornea-preferred gene promoter in transgenic mice
PNAS, December 9, 1997; 94(25): 13594 - 13599.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Adler, A.às Schaffer, J. Kim, L. Dolan, and Z.'e. Ronai
UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways
J. Biol. Chem., November 3, 1995; 270(44): 26071 - 26077.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.