Nucleic Acids Research, 1992, Vol. 20, No. 18 4919-4925
© 1992
MOLECULAR BIOLOGY |
A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system
The Howard Hughes Medical Institute and the Departments of Biochemistry Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 1Molecular Genetics Section Pediatric Branch, National Institutes of Health, Bethesda, MD 2Jefferson Cancer Center Thomas Jefferson University, Philadelphia, PA 3Department of Neurological Surgery and Pediatrics Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA 4Institut für Molekularbiologie und Tumorforschung Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA 5Department of Microbiology Albert Einstein University, Bronx, NY, USA
*To whom correspondence should be addressed at: Howard Hughes Medical MA 02115, USA Institute at Children's Hospital, Enders 861, 300 Longwood Avenue, Boston
Received February 10, 1992. Revised July 17, 1992. Accepted July 17, 1992.
We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC encoded protein Is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila1-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepfthellomas and Ewing's sarcomas but not neuroblastomas.Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.
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