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Nucleic Acids Research, 1992, Vol. 20, No. 19 5215-5221
© 1992

MOLECULAR BIOLOGY

Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity

Terry Y.-K. Chow*, Edward L. Perkins1 and Michael A. Resnick1

Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, University of Sherbrooke Sherbrooke, Quebec J1H 5N4, Canada 1Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences PO Box 12233, Research Triangle Park, NC 27709, USA

* To whom correspondence should be addressed

Received March 2, 1992. Revised August 4, 1992. Accepted August 4, 1992.

The yeast Saccharomyces cerevisiae contains an endoexonuclease yNucR that has been implicated in both recombination and repair. We describe the isolation and characterization of the corresponding gene. Within the predicted N-terminal half of the protein there is extensive homology (approximately 50%) with human rho genes, which are related to the ras oncogene, particularly in the proposed GTP-binding region. The C-terminal region, which is related to the Escherichia coli recC protein, presumably encodes the endoexonuclease activity. The yNucR may thus represent a new class of GTP-bindlng proteins. Because of the chimeric nature of the polypeptide, this protein is renamed RhoNUC (rather than the original yNucR) and the gene is RNC1 for Rho-associated-NuClease. Over expression of the gene leads to altered cell growth and nuclear morphology. We propose that the gene plays an important role in cell development as well as DNA repair/recombination.


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