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Nucleic Acids Research, 1992, Vol. 20, No. 2 263-266
© 1992

MOLECULAR BIOLOGY

S1 nuclease hypersensitive sites in an oligopurine/oligopyrimidine DNA from the t(10;14) breakpoint cluster region

Ming Lu, Nan Zhang, Susana Raimondi1 and Anthony D. Ho

Northeastern Ontario Regional Cancer Centre and Department of Medicine, University of Ottawa 41 Ramsey Lake Rd, Sudbury, Ontario P3E 5J1, Canada 1The St. Jude Children's Research Hospital 332 North Lauderdale, PO Box 318, Memphis, TN 38101-0318, USA

Received October 15, 1991. Accepted December 14, 1991.

Recurring chromosomal translocations are frequently seen in cancers, especially on leukemias and lymphomas. The genes affected by these chromosomal translocations appear to play an important role in oncogenesis. The mechanism underlying the formation of chromosomal translocation is a subject under extensive study. In chromosomal translocations involving the lg and TCR loci, complete heptamer-spacer-nonammer signal motifs are usually present at the break of the lg and TCR genes, indicating the involvement off V-D-J recombinase(s). On the other band, in only about 50% of the cases signal motif sequences have been found at the break in the other participating chromosome, suggesting that different mechanisms may be involved in the scission of the corresponding chromosome. Here we report the identification of an oligopurine/oligopyrimidine DNA in the t(10; 14) breakpoint cluster region associated with T-cell acute lymphoblastic leukemia. SI nuclease mapping revealed multiple S1 hypersensitive sites in the oligopurine/oligopyrimine DNA. These data suggest a role for oligopurine/oligopyrimidine sequences (non-B DNA) in the formation of chromosomal translocation.


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