Nucleic Acids Research, 1992, Vol. 20, No. 2 343-350
© 1992
GENOME STRUCTURE AND MAPPING |
Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promotero
Department of Molecular Biology, Bristol-Mayers Squibb Pharmaceutical Research Institute PO Box 4000, Princeton, NJ 08543–74000, USA 1Institut National de la Santé et de la Recherche Médicale U242, Centre de Génétique Médicale, Hospital d'Enfants de la Timone 13385 Marseille, France
*To whom correspondence should be addressed
Received August 13, 1991. Revised November 25, 1991. Accepted November 25, 1991.
We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a region upstream of the TATA box which is the promoter region of the gene. Several consensus sequences have been identified, including an SRE and AP-1 binding site whose relative positions are identical to those in the 5'upstream region of the c-fos gene. We have also shown that FosB and c-Fos can downregulate the activity of the fosB promoter to a similar extent. The fosB gene is located in the [A1-B1] region of mouse chromosome 7.
+Present address: Departmento Biologia Funcional, Facultad de Medicina, E-33071 Oviedo. Spain
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