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Nucleic Acids Research, 1992, Vol. 20, No. 20 5429-5434
© 1992

MOLECULAR BIOLOGY

Characterization of a novel T lymphocyte protein which binds to a site related to steroid/thyroid hormone receptor response elements in the negative regulatory sequence of the human immunodeficiency virus long terminal repeat

Kim Orchard, Georgina Lang, Mary Collins and David Latchman1,*

Chester Beatty Laboratories, Institute of Cancer Research 237 Fulham Road, London SW3 6JB, UK 1Medical Molecular Biology Unit, Department of Biochemistry, Division of Molecular Pathology The Windeyer Building, Cleveland Street, London W1P 6DB, UK

* To whom correspondence should be addressed

Received June 24, 1992. Revised September 25, 1992. Accepted September 25, 1992.

We have previously identified a T lymphocyte protein which binds to a site within the LTR of the human immunodeficiency virus type 1 (HIV-1) and exerts an inhibitory effect on virus gene expression. The palindromic site (site B) recognized by this protein is related to the palindromic binding sites of members of the steroid/thyroid hormone receptor family. Here we characterize the T cell protein binding to this site as a 100 kD protein which is most abundant in T cells and which binds to site B as a 200 kD complex. This protein Is distinct from other members of the steroid/thyroid hormone receptor family including the COUP protein which has a closely related DNA binding specificity.


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