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Nucleic Acids Research, 1992, Vol. 20, No. 20 5465-5472
© 1992

MOLECULAR BIOLOGY

The basic RNA-binding domain of HIV-2 Tat contributes to preferential trans-activation of a TAR2-containing LTR

Yung-nien Chang and Kuan-Teh Jeang*

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases Bethesda, MD 20892, USA

* To whom correspondence should be addressed at Building 4, Room 306, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA

Received March 25, 1992. Revised September 16, 1992. Accepted September 16, 1992.

Human immunodeficiency viruses HIV-1 and HIV-2 encode a Tat protein that trans-activates the respective viral genome through RNA targets (TAR1 and TAR2). Tat-1 and Tat-2 have considerable homology. However, an interesting biological observation has been that Tat-1 activates the HIV-1 and HIV-2 LTRs equally while Tat-2 activates the former, In comparison to the latter, poorly. Here, we present evidence that it is the TAR2 RNA target together with the basic RNA-binding protein domain of Tat-2 that dictate this non-reciprocity in trans-activation.


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