Nucleic Acids Research, 1992, Vol. 20, No. 21 5661-5667
© 1992
MOLECULAR BIOLOGY |
Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells
Chester Beatty Laboratories, Institute of Cancer Research 237 Fulham Road, London SW3 6JB, UK
* To whom correspondence should be addressed
Received July 29, 1992. Revised September 30, 1992. Accepted September 30, 1992.
This paper describes the characterisation of a novel chicken homeobox gene, Prh, whose encoded homeodomain sequence differs significantly from those of other factors which have been described. As expected, a portion of the encoded protein, containing the homeodomain, is capable of sequence-specific DNA-binding. Outside the homeodomain, Prh, possesses an N-terminal region extremely rich in proline residues and a C-terminal acidic portion, either of which may function as transcription regulatory domains. Since, among the chicken tissues tested, its transcription is restricted to haematopoietic cells, lung and liver, it may function in tissue-specific patterns of gene regulation. Human and murine Prh homologues have also been identified; so it is likely that such genes are a general feature of vertebrate genomes.
+Present addresses: The Institute of Cancer Research, Royal Cancer Hospital, Haddow Laboratories, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
Universita di Trieste, Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Trieste, Italy
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