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Nucleic Acids Research, 1992, Vol. 20, No. 21 5677-5686
© 1992

MOLECULAR BIOLOGY

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S.cerevisiae

Andreas Hartig, Manuel M. Simon, Tillman Schuster1, Jon R. Daugherty2, Hyang Sook Yoo2 and Terrance G. Cooper2,*

Institut fuer Allgemeine Biochemie der Universitaet und Ludwig Boltzmann-Forschungsstelle fuer Biochemie Dr. Bohrgasse 9, A-1030 Wien 1Institute of Molecular Pathology Dr. Bohrgasse 7, A-1030 Wien, Austria 2Department of Microbiology and Immunology, University of Tennessee Memphis, TN 38163, USA

* To whom correspondence should be addressed

Received July 24, 1992. Revised October 1, 1992. Accepted October 1, 1992.

We have isolated a second gene (MLS1), which in addition to DAL7, encodes malate synthase from S.cerevisiae. Expression of the two genes is specific for their physiological roles in carbon and nitrogen metabolism. Expression of MLS1, which participates in the utilization of non-fermentable carbon sources, is sensitive to carbon catabolite repression, but nearly insensitive to nitrogen catabolite repression. DAL7, which participates in catabolism of the nitrogenous compound allantoin, is insensitive to carbon catabolite repression, but highly sensitive to nitrogen catabolite repression. Results obtained with null mutations in these genes suggest that S.cerevisiae contains at least one and perhaps two additional malate synthase genes.


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