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Nucleic Acids Research, 1992, Vol. 20, No. 22 5907-5910
© 1992

MOLECULAR BIOLOGY

Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation

J. Sanders, J.A. Maassen and W. Möller*

Department of Medical Biochemistry, Sylvius Laboratory, State University of Leiden PO Box 9503, 2300 RA Leiden, The Netherlands

* To whom correspondence should be addressed

Received September 7, 1992. Revised October 16, 1992. Accepted October 16, 1992.

Copy-DNA clones covering the complete coding sequence of human Elongation Factor-17 mRNA have been isolated and characterized. The expression of Elongation Factor-1 in a variety of cell lines and a number of tissues shows a large increase in Elongation Factor-1{gamma} mRNA going from tissue to cultured cells (20-fold). Messenger-RNA levels for Elongation Factor-17{alpha}, -1ß and -I{gamma} increase in parallel suggesting coordinate regulation of the expression of these genes. Oncogenic transformation in vitro does not strongly affect Elongation Factor-1 mRNA levels.


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