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Nucleic Acids Research, 1992, Vol. 20, No. 24 6495-6499
© 1992

MOLECULAR BIOLOGY

SEF1 binding is important for T cell specific enhancers of genes for T cell receptor-CD3 subunits

Bengt Hallberg+, Anders Thornell, Magnus Holm and Thomas Grundström*

Department of Applied Cell and Molecular Biology, University of Umeå S-901 87 Umeå, Sweden

*To whom correspondence should be addressed

Received October 13, 1992. Revised November 30, 1992. Accepted November 30, 1992.

A family of proteins, denoted SL3-3 enhancer factor 1 (SEF1), interacts with DNA sequences in the T cell specific enhancer of SL3-3 murine leukemia virus and in the enhancers of several other viruses. A putative SEF1 binding site was also identified in the T cell specific enhancer of the gene encoding the human T cell antigen receptor (TcR) associated CD3-{varepsilon} polypeptide. In this study we show that the identified sequence is a strong SEF1 binding site, and that purified SEF1 proteins bind specifically to the sequence. We report also that the SEF1 binding site is important for T cell specific activation of transcription by the CD3-{varepsilon} enhancer. We show that SEF1 binding sites are present also in the T cell specific enhancers of other subunits of the TcR-CD3 complex, and that SEF1 proteins appear to play a central role in the T cell specific expression of this set of enhancers.

+ Present address: Signal Transduction Lab., Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK


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