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Nucleic Acids Research, 1992, Vol. 20, No. 24 6501-6507
© 1992

GENOME STRUCTURE AND MAPPING

Modular organization of related Archaeal plasmids encoding different restriction-modification systems in Methanobacterium thermoformicicum

Jörk Nölling, Freek J.M.van Eeden, Rik I.L. Eggen and Willem M. de Vos*

Bacterial Genetics Group, Department of Microbiology, Wageningen Agricultural University Hesselink van Suchtelenweg 4, 6703 CT Wageningen, The Netherlands

*To whom correspondence should be addressed

Received October 8, 1992. Revised November 23, 1992. Accepted November 23, 1992.

Nucleotide sequence comparison of the related 13513-bp plasmld pFV1 and the 11014-bp plasmid pFZ1 from the thermophilic archaeon Methanobacterium thermoformicicum THF and Z-245, respectively, revealed a homologous, approximately 8.2 kb backbone structure that is interrupted by plasmid-specific elements. Various highly conserved palindromic structures and an ORF that could code for a NTP-binding protein were Identified within the backbone structure and may be involved in plasmid maintenance and replication. Each plasmid contains at comparable locations a module which specifies components of different restriction-modification (R/M) systems. The R/M module of pFV1 contained, in addition to the genes of the GGCC-recognizlng R/M system MthTI, an ORF which may be involved in repair of G-T mismatches generated by deamination of m5C at high temperatures.


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