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Nucleic Acids Research, 1992, Vol. 20, No. 3 421-423
© 1992

MOLECULAR BIOLOGY

The acceptor stem in pre-tRNAs determines the cleavage specificity of RNase P

Per S. Holm+ and Guido Krupp*

Institute for General Microbiology, Christian-Albrechts-Universität Am Botanischen Garten 9, W-2300 Kiel, FRG

*To whom correspondence should be addressed

Received November 15, 1991. Revised December 23, 1991. Accepted December 23, 1991.

As the result of an unusual RNase P specificity, some special, mature tRNAs have acceptor stems with eight instead of the common seven base pairs. The data from numerous studies suggest that some features in the tRNA domain of pre-tRNAs are important for this behaviour. Here, we show that only five base pairs in the acceptor stem of bacterial histidine tRNAs are required to obtain the changed cleavage site in an unrelated eukaryotic serine tRNA.


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