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Nucleic Acids Research, 1992, Vol. 20, No. 3 507-511
© 1992

MOLECULAR BIOLOGY

Formation of novel hairpin structures by telemeric C-strand oligonucleotides

Shawn Ahmed and Eric Henderson*

Department of Zoology and Genetics, 339 Science II, Iowa State University Ames, IA 50011, USA

*To whom correspondence should be addressed

Received October 9, 1991. Revised December 17, 1991. Accepted December 17, 1991.

Telomeres are specialized structures at the ends of chromosomes that are required for long term chromosome stability and replication of the chromosomal terminus. Telomeric DNA consists of simple repetitive sequences with one strand G-rich relative to the other, C-rich, strand. Evolutionary conservation of this feature of telomeric repeat sequences suggests that they have specific structural characteristics involved in telomere function. Absorbance thermal denaturation, chemical modification and non-denaturing gel electrophoretic analyses showed that telomeric C-strand oligonucIeotides form stable non-Watson-Crick hairpin structures containing C.C+ base pairs.Formation of such hairpins may facilitate previously reported G-strand exclusive interactions.


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