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Nucleic Acids Research, 1992, Vol. 20, No. 4 879-887
© 1992

Articles

Homologies between the contiguous and fragmented rRNAs of the two Plasmodium falciparum extrachromosomal DNAs are limited to core sequences

Jean E. Feagin, Erica Werner, Malcolm J. Gardner1, Donald H. Williamson1 and Robert J.M. Wilson1

Seattle Biomedical Research Institute 4 Nickerson St, Seattle, WA 98109-1651, UK 1Division of Parasitology, National Institute for Medical Research The Ridgeway, Mill Hill, London NW7 1AA, UK

Received September 5, 1991. Revised January 13, 1992. Accepted January 13, 1992.

Plasmodium faiciparum contains two extrachromosomal DNAs, a 6 kb linear element and a 35 kb circular DNA; both encode rONA sequences. The 6 kb element rDNAs comprise fragments of both large and small subunit rRNAs. Comparison of these with corresponding rDNA sequences from the 35 kb DNA and E. coli show that sequences conserved between the three are largely confined to highly conserved core regions; in fact, most of the 6 kb rDNA sequences correspond to core regions. Both the 6 kb element and 35 kb rDNAs show less conservation to each other than to E. coli sequences, suggesting that the two extrachromosomal DNAs ofP. faiciparum are not closely related. The characteristics of the fragmented rRNAs from the 6 kb element suggest they are functional, possibly in mitochondrial ribosomes.


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