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Nucleic Acids Research, 1992, Vol. 20, No. 5 1087-1091
© 1992

MOLECULAR BIOLOGY

Evolutionary variation of the CCAAT-binding transcription factor NF-Y

Xiao-Yan Li, Roberto Mantovani, Rob Hooft van Huijsduijnen, Isabelle Andre, Christophe Benoist* and Diane Mathis

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moleculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine Strasbourg, France

*To whom correspondence should be addressed

Received November 21, 1991. Revised February 3, 1992. Accepted February 3, 1992.

NF-Y is a CCAAT-speclfic transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in Isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subunlt interaction; more evolutionatily flexible flanking regions, In which variability is clustered, individualizing conserved glutamine or acidic amino-acids putatively involved in protein-protein contacts.


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