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Nucleic Acids Research, 1992, Vol. 20, No. 6 1243-1249
© 1992

MOLECULAR BIOLOGY

The rat poly Pyrimidine Tract binding protein (PTB) interacts with a single-stranded DNA motif in a liver-specific enhancer

Pidder Jansen-Dürr, Michael Boshart, Barbara Lupp, Armin Bosserhoff1, Rainer W. Frank1 and Günther Schütz*

Institute of Cell and Tumor Biology, German Cancer Research Center Im Neuenheimer Feld 280, D-6900 Heidelberg 1, Germany 1ZMBH, Im Neuenheimer Feld 282 D-6900 Heidelberg, Germany

*To whom correspondence should be addressed

Received January 7, 1992. Revised February 24, 1992. Accepted February 24, 1992.

we characterized and purified a protien from rat liver which specifically binds to a DNA motrif present in a liver-specific enhancer of the rat tyrosine aminotransferase (TAT) gene, when offered as single-stranded DNA. Binding is highly sequence-specific and coincides with a region known to be essential for function of the enhancer. Microsequencing revealed that this protein is the rat homilogue of the mouse and human poly Pyramidine Tract binding protein (PTB), which has been shopwn to bind to premRNA and may participate in RNA splicing. This finding was corroboratede by subsequent Western blot experiments using a PTB-specific anitbody. These findings indicate a possible dual role for this protein in RNBA processing and transcription.


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