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Nucleic Acids Research, 1992, Vol. 20, No. 6 1387-1391
© 1992

MOLECULAR BIOLOGY

A protein which specifically binds to single stranded TTAGGGn repeats

Stewart J. McKay and Howard Cooke*

Medical Research Council Human Genetics Unit, Western General Hospital Crewe Road, Edinburgh EH4 2XU, UK

*To whom correspondence should be addressed

Received October 16, 1991. Revised February 18, 1992. Accepted February 18, 1992.

Nuclei from tissues of many vertebrates contain a soluble 37 kd protein which binds with a high degree of specificity to oligonucleotides which contain the G rich strand of the telomertc terminal repeats, TTAGGG. In some tissues this Is an abundant nuclear protein.


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