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Nucleic Acids Research, 1992, Vol. 20, No. 9 2211-2215
© 1992

MOLECULAR BIOLOGY

Kluyveromyces contains a functional ABF1-homologue

Paula M. Gonçalves, Kick Maurer, Willem H. Mager and Rudi J. Planta*

Department of Biochemistry and Molecular Biology, Vrije Universiteit de Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

*To whom correspondence should be addressed

Received February 28, 1992. Revised April 2, 1992. Accepted April 2, 1992.

ABF1 is a multifunctional protein present in Saccharomyces cerevisiae, involved in transcription-activation and -repression as well as in DNA-replication. Several lines of evidence indicate the occurrence in the related species Kluyveromyces lactis of a protein having similar properties to those of ABF1 in S.cerevisiae. In order to identify conserved functional domains in ABF1, we have cloned and sequenced the gene encoding the ABF1-homologue from K. lactis. KIABF1 is much smaller than ScABF1 (54.6 vs. 81.7 kD). It exhibits extensive homology with its S.cerevisiae counterpart in the N-terminal region. The C- terminal domain however, is divergent, with the striking exception of a stretch of 20 amino acids, which is virtually identical in the two proteins. KIABF1 can substitute ABF1 in S. cerevisiae, emphasizing the conservation of the multiple functions of this protein.


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