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Nucleic Acids Research, 1992, Vol. 20, No. 9 2271-2278
© 1992

MOLECULAR BIOLOGY

The swi4+ gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes

Oliver Fleck, Holger Michael and Lutz Heim1

Institut für Genetik, Biozentrum, Technische Universität Braunschweig Konstantin-Uhde-Strasse 5, W-3300 Braunschweig, Germany 1Max-Planck-Institut für Biophysikalische Chemie Am Fassberg, W-3400 Göttingen, Germany

Received February 4, 1992. Revised April 3, 1992. Accepted April 3, 1992.

The swi4+ gene of Schizosaccharomyces pombe is involved in termination of copy-synthesis during mating-type switching. The gene was cloned by functional complementation of a swi4 mutant transformed with a genomic library. Determination of the nucleotide sequence revealed an open reading frame of 2979 nucleotides which is interrupted by a 68 bp long intron. The putative Swi4 protein shows homology to Duc-1 (human), Rep-3 (mouse), HexA (Streptococcus pneumoniae) and MutS (Salmonella typhimurium). The prokaryotic proteins are known as essential components involved in mismatch repair. A strain with a disrupted swi4 gene was constructed and analysed with respect to the switching process. As in swi4 mutants duplications occur in the mating-type region of the swi4 (null) strain, reducing the efficiency of switching.


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