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Nucleic Acids Research, 1993, Vol. 21, No. 1 127-134
© 1993

MOLECULAR BIOLOGY

Cloning. chromosomal localization and expression pattern of the POU domain gene Oct-11

Andrew S. Goldsborough+, Lyn E. Healy, Neal G. Copeland1, Debra J. Gilbert1, Nancy A. Jenkins1, Keith R. Willison and Alan Ashworth*

Chester Beatty Laboratories, Institute of Cancer Research Fulham Road, london SW3 6JB, UK 1Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center Frederick, MD 21702, USA

*To whom correspondence should be addressed

Received September 4, 1992. Accepted November 23, 1992.

POU domain genes encode a family of highly conserved transacting factors that influence the transcriptional activity of several cell type-specific and ubiquitous genes. We have cloned and sequenced cDNAs encoding a novel mouse POU domain protein, Oct-11, that is closely related within the POU domain to the POU class II proteins, Oct-1 and Oct-2. Recombinant Oct-11 protein binds specifically to an octamer sequence in vitro. The Oct-11 gene Is expressed during mouse embryogenesls and in the adult thymus and testis. In addition, it is abundant in the myeloma cell line P3NS-11-Ag4.1. We describe the structure of Oct-11 and its chromosomal localization, and discuss the evidence that the POU class II gene family has evolved by duplication and divergence of a common ancestral gene.

+Present Address: University of California, School of Medicine, Department of Biochemistry, San Francisco, CA 94143-0554, USA


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