Skip Navigation

This Article
Right arrow Print PDF (604K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (67)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Degnan, B. M.
Right arrow Articles by Morse, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Degnan, B. M.
Right arrow Articles by Morse, D. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1993, Vol. 21, No. 15 3479-3484
© 1993

MOLECULAR BIOLOGY

The ets multigene family is conserved throughout the Metazoa

Bernard M. Degnan+, Sandie M. Degnan+, Takeshi Naganuma§ and Daniel E. Morse*

Marine Biotechnology Center and Department of Biological Sciences, University of California Santa Barbara, CA 93106, USA

*To whom correspondence should be addressed

Received April 15, 1993. Revised June 11, 1993. Accepted June 11, 1993.

This study provides the first empirical evidence for the conservation of the ets proto-oncogene transcription factor family throughout the Metazoa. Using the polymerase chain reaction with degenerate primers corresponding to conserved sequences within the ETS DNA-binding domain, we have detected ets genes in a range of lower metazoans, including sponges, ctenophores, anemones, flatworms and nematodes, and in severai higher invertebrate metazoans. Many of these sequences are significantly divergent from the original v-eta-1 oncogene, although most can be aligned with recently defined groups within the ets gene family. Multiple ETS domain sequences were detected in a number of the lower metazoan species, providing evidence for the existence of an ets multigene family at the earliest stages of metazoan evolution. In contrast, we were unable to detect any ETS sequences in fungal, plant or several protozoan DNAs. Our findings suggest that the duplication and divergence of ets proto-oncogenes responsible for generating the multigene family occurred concomitantly with the development of metazoan animals. In addition, these data corroborate other recent molecular evidence in providing strong support for the monophyletic origin of all multicellular animals, including sponges.

+Present address: Department of Zoology, University of Queensland, Brisbane, Queensland 4072, Australia

§Present address: Deep Star Program, Japan Marine Science and Technology Center, 2–15 Natsushima-cho, Yokosuka, Kanagawa 237. Japan


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
T. Higuchi, F. O. Bartel, M. Masuya, T. Deguchi, K. W. Henderson, R. Li, R. C. Muise-Helmericks, M. J. Kern, D. K. Watson, and D. D. Spyropoulos
Thymomegaly, Microsplenia, and Defective Homeostatic Proliferation of Peripheral Lymphocytes in p51-Ets1 Isoform-Specific Null Mice
Mol. Cell. Biol., May 1, 2007; 27(9): 3353 - 3366.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Carella, M. Potter, J. Bonten, J. E. Rehg, G. Neale, and G. C. Grosveld
The ETS factor TEL2 is a hematopoietic oncoprotein
Blood, February 1, 2006; 107(3): 1124 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Yamada, M. Okabe, and Y. Hiromi
EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed
Development, September 1, 2003; 130(17): 4085 - 4096.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Bull.Home page
S. P. Leys and B. M. Degnan
Cytological Basis of Photoresponsive Behavior in a Sponge Larva
Biol. Bull., December 1, 2001; 201(3): 323 - 338.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Anderson, G Hernandez-Hoyos, R. Diamond, and E. Rothenberg
Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage
Development, January 6, 1999; 126(14): 3131 - 3148.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
P. Shore, L. Bisset, J. Lakey, J. P. Waltho, R. Virden, and A. D. Sharrocks
Characterization of the Elk-1 ETS DNA-binding Domain
J. Biol. Chem., March 17, 1995; 270(11): 5805 - 5811.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. K. Anderson, X. Sun, A. L. Miracle, G. W. Litman, and E. V. Rothenberg
Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria
PNAS, January 16, 2001; 98(2): 553 - 558.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.