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Nucleic Acids Research, 1993, Vol. 21, No. 18 4226-4230
© 1993

MOLECULAR BIOLOGY

Increase in the basal transcriptional activity of the human foamy virus internal promoter by the homologous long terminal repeat promoter in cis

Martin Loöchelt, Mordechai Aboud1 and Rolf M. Fluügel*

Abteilung Retrovirale Genexpression, Forschugsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungsezentrum, Im Neuenhei9mer Feld 242, 69009 Heidel berg, Germany 1Department of Microbiology and Immunology, Faculty of Health Sciences, Ben-Gurion University of the Negev Beer sheva, Israel

*To whom correspondence should be addressed

Received June 10, 1993. Revised August 10, 1993. Accepted August 10, 1993.

The human foamy or spumaretrovlrus HFV is a complex and exogenous retrovirus that encodes several bel genes besides the three classical retrovtral genes gag, pol, and env. HFV was recently reported to contain two functionally active promoters that are both strongly trans-activated by the HFV trans-activator protein Bel 1. The occurrence of a second internal cap site underscores the complexity of the HFV genome. We have analysed whether there is interference between the HFV long terminal repeat promoter and the internal promoter located In the 3' end of env upstream of the bel genes. Recomblnant clones were constructed that carry two different indicator genes, one under the control of the U3 promoter, the other under the control of the Internal promoter. The portion of the basal transcriptional activity of the Internal promoter that is not trans-activated by Bel 1 was Increased two- to threefold in the presence of the long terminal repeat promoter. The rate of trans-activation by Bel 1 of both HFV promoters was not altered in these constructs.


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