Skip Navigation

This Article
Right arrow Print PDF (657K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (43)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by corell, R. A.
Right arrow Articles by Stuart, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by corell, R. A.
Right arrow Articles by Stuart, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1993, Vol. 21, No. 18 4313-4320
© 1993

MOLECULAR BIOLOGY

Trypanosoma brucei minicricles encode multiple guide RNAs which can direct editing of extensively overlapping sequences

Robert A. corell1, Jean E. Feagin1,2, George R. Riley1, Tricia Strickland1, Jeffrey A. Guderian1, Peter J. Myler1,2 and Kenneth Stuart1,2,*

1Seattle Biomedical Research Institute 4 Nickerson Street, Seattle, WA 98109-1651 2Department of Pathobiology, University of Washington SC-38, Seattle, WA 98195, USA

*To whom correspondence should be addressed

Received May 19, 1993. Revised August 6, 1993. Accepted August 6, 1993.

Small guide RNAs (gRNAs) may direct RNA editing In kinetoplastid mitochondria. We have characterized multiple gRNA genes from Trypanosoma brucei (EATRO 164), that can specify up to 30% of the editing of the COIN, ND7, ND8, and A6 mRNAs and we have also found that the non-translated region of edited COIN mRNA of strain (EATRO 164) differs from that of another strain. Several of the gRNAs specify overlapping regions of the same mRNA often specifying sequence beyond that required for an anchor duplex with the next gRNA. Some gRNAs have different sequence but specify identical editing of the same region of mRNA. These data Indicate a complex gRNA population and consequent complex pattern of editing in T.brucel.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
V. S. Alatortsev, J. Cruz-Reyes, A. G. Zhelonkina, and B. Sollner-Webb
Trypanosoma brucei RNA Editing: Coupled Cycles of U Deletion Reveal Processive Activity of the Editing Complex
Mol. Cell. Biol., April 1, 2008; 28(7): 2437 - 2445.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
T. Ochsenreiter, M. Cipriano, and S. L. Hajduk
KISS: The kinetoplastid RNA editing sequence search tool
RNA, January 1, 2007; 13(1): 1 - 4.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Simpson, O. H. Thiemann, N. J. Savill, J. D. Alfonzo, and D. A. Maslov
Evolution of RNA editing in trypanosome mitochondria
PNAS, June 20, 2000; 97(13): 6986 - 6993.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Pelletier, M. M. Miller, and L. K. Read
RNA-binding properties of the mitochondrial Y-box protein RBP16
Nucleic Acids Res., March 1, 2000; 28(5): 1266 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. M. Visomirski-Robic and J. M. Gott
Insertional editing of nascent mitochondrial RNAs in Physarum
PNAS, April 29, 1997; 94(9): 4324 - 4329.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. J. Connell, E. M. Byrne, and L. Simpson
Guide RNA-independent and Guide RNA-dependent Uridine Insertion into Cytochrome b mRNA in a Mitochondrial Lysate from Leishmania tarentolae. ROLE OF RNA SECONDARY STRUCTURE
J. Biol. Chem., February 14, 1997; 272(7): 4212 - 4218.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L Simpson and D. Maslov
RNA editing and the evolution of parasites
Science, June 24, 1994; 264(5167): 1870 - 1871.
[PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.