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Nucleic Acids Research, 1993, Vol. 21, No. 19 4506-4510
© 1993

MOLECULAR BIOLOGY

Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains

Peter J. Morris, Christopher J.A. Ring, Karen A. Lillycrop and David S. Latchman*

Division of Molecular Pathology, University College London Medical School The Windeyer Building, Clevel and Street, London W1P 6DB, UK

*To whom correspondence should be addressed

Received June 21, 1993. Revised August 20, 1993. Accepted August 10, 1993.

The upstream regulatory region (URR) of the human papillomaviruses HPV16 and 18 contains a sequence with a seven out of eight base match to the consensus binding site for octamer binding transcription factors. This motif acts as a target for repression by the Oct-1 transcription factor and therefore inhibits promoter activity in non-cervical cells expressing only Oct-1. In contrast the HPV octamer motif activates promoter activity in cervical cells. Here we show that cervical cells express the activating form of the Oct-2 transcription factor, Oct 2.1 and that this factor can transactivate promoter activity via the HPV16 octamer. This effect is dependent upon both the N and Cterminal activation domains of Oct-2. The expression of specific octamer binding proteins such as Oct-2 in cervical cells thus allows the HPV16 motif to produce opposite effects on gene expression in cervical and non-cervical cells suggesting that it may play a role in the cervical specificity of URR driven gene expression.


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[Abstract] [Full Text] [PDF]


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