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Nucleic Acids Research, 1993, Vol. 21, No. 22 5124-5129
© 1993

MOLECULAR BIOLOGY

Novel internal promoterminusb;enhancer of HTLV-I for Tax expression

Tetsuya Nosaka, Yasuo Ariumi, Mamoru Sakurai, Ryo Takeuchi and Masakazu Hatanaka*

Institute for Virus Research, Kyoto University Sakyo-ku, Kyoto 606-01, Japan

*To whom correspondence should be addressed

Received July 27, 1993. Revised October 6, 1993. Accepted October 6, 1993.

The transcription initiation signals in retroviruses lie within the long terminal repeat (LTR) sequences. We have found a new transcriptional promoter in a central portion of the genome of human T-cell leukaemia virus type I (HTLV-I). The transcription start site is located just upstream to the ATG codon of the transcriptional frans-activator molecule, tax protein (Tax). The internal promoter may provide a new insight into gene expression of HTLV-I. The mechanism of leukaemogenesis by the defective HTLV-I is also discussed. Furthermore, we have identified two repeats of a novel enhancer sequence AGTTCT, which are located around the initiation site. We call the sequence HIRE (HTLV-I Internal Regulatory Element).


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