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Nucleic Acids Research, 1993, Vol. 21, No. 25 5964-5971
© 1993

MOLECULAR BIOLOGY

Cloning and characterisation of the Schizosaccharomyces pombe rad8 gene, a member of the SNF2 helicase family

Claudette L. Doe, Johanne M. Murray, Maryam Shayeghi, Marie Hoskins1, Alan R. Lehmann1, Antony M. Carr1 and Felicity Z. Watts

School of Biological Sciences, University of Sussex, Falmer Brighton, East Sussex BN1 9QG 1MRC Cell Mutation Unit, University of Sussex, Brighton East Sussex BN1 9RR, UK

*To whom correspondence should be addressed

Received August 23, 1993. Revised November 22, 1993. Accepted November 22, 1993.

Degenerate oligonucleotides encoding conserved regions of the Rad52 protein of S.cerevisiae and its homologue, the Rad22 protein of S.pombe, were used to clone a chicken RAD52 counterpart by the polymerase chain reaction. Sequence comparison of the chicken and yeast proteins reveals a strongly conserved region between positions 40 and 178 of the chicken Rad52 sequence indicating that this part of the protein is under strong evolutionary pressure. The first 39 amino acids and the 3' end of the chicken Rad52 homologue does not share significant similarity with the yeast proteins. High abundance of the mRNA in testis makes it likely that the chicken Rad52 protein plays a role in meiotic recombination.


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