Nucleic Acids Research, 1993, Vol. 21, No. 5 1087-1095
© 1993
MOLECULAR BIOLOGY |
Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development
Department of Biochemistry and Genetics, Medical School, University of Newcastle upon Tyne Newcastle upon Tyne NE2 4HH, UK
* To whom correspondence should be addressed
Received December 22, 1992. Accepted January 18, 1993.
To begin to examine the function of genes that control early development in the hindbraln, we have screened an embryonic zebrafish cDNA library with a murine krox-20 gene probe that contained the conserved zinc finger regions. We have isolated two overlapping cDNAs, zf187 and zf201 which are homologues of the murlne krox-20 gene. The N-termlnal of the longest cDNA (zf201) contains two acidic regions identical to those of the murlne krox-20. This indicates that the functional organisation of these proteins is probably conserved. Northern Blot analysis identified a single transcript of 2.0 kb. Wholemount in situ hybridisation established that expression of the zebraflsh gene (krx-20) first appears at 100% eplboly as a single anterior domain of the prospective neuroeplthelium, followed very soon after by a second more posterior domain. The alternating pattern of expression of this gene In rhombomeres(r) r3 and r5 is apparent by 12 hr post-fertilisation, that Is prior to the morphological appearance of the rhombomeres. Around 14 hr neural crest migration begins from the dorsal surface of r5, moving caudally Into r6 and then ventrally towards the pharyngeal arches. Crest migration is not apparent at or after 16 hr. No neural crest migration was observed from r3. Expression of krx-20 is down regulated firstly in r3 around 26 hr and later in r5 around 30 hr.
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G. Begemann, T. F. Schilling, G.-J. Rauch, R. Geisler, and P. W. Ingham The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain Development, August 15, 2001; 128(16): 3081 - 3094. [Abstract] [Full Text] [PDF]
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J. M. McClintock, R. Carlson, D. M. Mann, and V. E. Prince Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes Development, July 1, 2001; 128(13): 2471 - 2484. [Abstract] [Full Text] [PDF]
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F. C. Serluca and M. C. Fishman Pre-pattern in the pronephric kidney field of zebrafish Development, June 15, 2001; 128(12): 2233 - 2241. [Abstract] [Full Text] [PDF]
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N Vlachakis, S. Choe, and C. Sagerstrom Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish Development, January 4, 2001; 128(8): 1299 - 1312. [Abstract] [PDF]
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H Bauer, Z Lele, G. Rauch, R Geisler, and M Hammerschmidt The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo Development, January 3, 2001; 128(6): 849 - 858. [Abstract] [PDF]
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K. Mintzer, M. Lee, G Runke, J Trout, M Whitman, and M. Mullins Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation Development, January 3, 2001; 128(6): 859 - 869. [Abstract] [PDF]
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J Cooke, C Moens, L Roth, L Durbin, K Shiomi, C Brennan, C Kimmel, S Wilson, and N Holder Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain Development, January 2, 2001; 128(4): 571 - 580. [Abstract] [PDF]
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A. Majumdar, K. Lun, M. Brand, and I. A. Drummond Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia Development, May 15, 2000; 127(10): 2089 - 2098. [Abstract] [PDF]
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K Fekany-Lee, E Gonzalez, V Miller-Bertoglio, and L Solnica-Krezel The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways Development, January 6, 2000; 127(11): 2333 - 2345. [Abstract] [PDF]
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H. Sirotkin, S. Dougan, A. Schier, and W. Talbot bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish Development, January 6, 2000; 127(12): 2583 - 2592. [Abstract] [PDF]
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V. Nguyen, J Trout, S. Connors, P Andermann, E Weinberg, and M. Mullins Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway Development, January 3, 2000; 127(6): 1209 - 1220. [Abstract] [PDF]
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R. Kelsh and J. Eisen The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives Development, January 2, 2000; 127(3): 515 - 525. [Abstract] [PDF]
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F Mechta-Grigoriou, S Garel, and P Charnay Nab proteins mediate a negative feedback loop controlling Krox-20 activity in the developing hindbrain Development, January 1, 2000; 127(1): 119 - 128. [Abstract] [PDF]
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A Dick, M Hild, H Bauer, Y Imai, H Maifeld, A. Schier, W. Talbot, T Bouwmeester, and M Hammerschmidt Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo Development, January 1, 2000; 127(2): 343 - 354. [Abstract] [PDF]
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Z. Varga, J Wegner, and M Westerfield Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops Development, January 12, 1999; 126(24): 5533 - 5546. [Abstract] [PDF]
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K. Artinger, A. Chitnis, M Mercola, and W Driever Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons Development, January 9, 1999; 126(18): 3969 - 3979. [Abstract] [PDF]
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A Chandrasekhar, H. Schauerte, P Haffter, and J. Kuwada The zebrafish detour gene is essential for cranial but not spinal motor neuron induction Development, January 6, 1999; 126(12): 2727 - 2737. [Abstract] [PDF]
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B. Bisgrove, J. Essner, and H. Yost Regulation of midline development by antagonism of lefty and nodal signaling Development, January 6, 1999; 126(14): 3253 - 3262. [Abstract] [PDF]
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K Fekany, Y Yamanaka, T Leung, H. Sirotkin, J Topczewski, M. Gates, M Hibi, A Renucci, D Stemple, A Radbill, et al. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures Development, January 4, 1999; 126(7): 1427 - 1438. [Abstract] [PDF]
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J Malicki and W Driever oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet Development, January 3, 1999; 126(6): 1235 - 1246. [Abstract] [PDF]
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M. Lackmann, A. C. Oates, M. Dottori, F. M. Smith, C. Do, M. Power, L. Kravets, and A. W. Boyd Distinct Subdomains of the EphA3 Receptor Mediate Ligand Binding and Receptor Dimerization J. Biol. Chem., August 7, 1998; 273(32): 20228 - 20237. [Abstract] [Full Text] [PDF]
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C Haddon, Y. Jiang, L Smithers, and J Lewis Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: evidence from the mind bomb mutant Development, January 12, 1998; 125(23): 4637 - 4644. [Abstract] [PDF]
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