Nucleic Acids Research, 1993, Vol. 21, No. 5 1193-1198
© 1993
MOLECULAR BIOLOGY |
The pre-mRNA binding K protein contains a novel evolutionary conserved motif
Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine Philadelphia, PA 19104-6148, USA
* To whom correspondence should be addressed
Received December 2, 1992. Revised January 23, 1993. Accepted January 23, 1993.
The K protein is among the major pre-mRNA-bindlng proteins (hnRNPs) in vertebrate cell nuclei. It binds tenaciously to cytidine-rich sequences and is the major oligo(rC/dC)-binding protein in vertebrate cells. We have cloned a cDNA of the Xenopus laevls hnRNP K and determined its sequence. The X.laevls hnRNP K Is a 47 kD protein that is remarkably similar to its human 66 kD counterpart except for two large internal deletions. The sequence of hnRNP K contains a 45 amino acid repeated motif which is almost completely conserved between the X.laevls and human proteins. We found that this repeated motif, the KH motif (for K homology), shows significant homology to several proteins some of which are known nucleic acids binding proteins. The homology is particularly strong with the archeabacterlal ribosomal protein S3 and with the saccharomyces cerevlslae protein MER1 which is required for melosls-speciflc splicing of the MER 2 transcript. As several of the proteins that contain the KH motif are known to bind RNA, this domain may be involved in RNA binding.
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B. D. Lang and J. L. Fridovich-Keil Scp160p, a multiple KH-domain protein, is a component of mRNP complexes in yeast Nucleic Acids Res., April 1, 2000; 28(7): 1576 - 1584. [Abstract] [Full Text] [PDF]
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T. M. Soliman and S. J. Silverstein Herpesvirus mRNAs Are Sorted for Export via Crm1-Dependent and -Independent Pathways J. Virol., March 15, 2000; 74(6): 2814 - 2825. [Abstract] [Full Text]
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J. Ostrowski, D. S. Schullery, O. N. Denisenko, Y. Higaki, J. Watts, R. Aebersold, L. Stempka, M. Gschwendt, and K. Bomsztyk Role of Tyrosine Phosphorylation in the Regulation of the Interaction of Heterogenous Nuclear Ribonucleoprotein K Protein with Its Protein and RNA Partners J. Biol. Chem., February 4, 2000; 275(5): 3619 - 3628. [Abstract] [Full Text] [PDF]
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R Clifford, M. Lee, S Nayak, M Ohmachi, F Giorgini, and T Schedl FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline Development, January 12, 2000; 127(24): 5265 - 5276. [Abstract] [PDF]
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D. Silvera, A. V. Gamarnik, and R. Andino The N-terminal K Homology Domain of the Poly(rC)-binding Protein Is a Major Determinant for Binding to the Poliovirus 5'-Untranslated Region and Acts as an Inhibitor of Viral Translation J. Biol. Chem., December 31, 1999; 274(53): 38163 - 38170. [Abstract] [Full Text] [PDF]
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J.-Y. Leu and G. S. Roeder Splicing of the Meiosis-Specific HOP2 Transcript Utilizes a Unique 5' Splice Site Mol. Cell. Biol., December 1, 1999; 19(12): 7933 - 7943. [Abstract] [Full Text] [PDF]
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B. Charroux, C. Angelats, L. Fasano, S. Kerridge, and C. Vola The Levels of the bancal Product, a Drosophila Homologue of Vertebrate hnRNP K Protein, Affect Cell Proliferation and Apoptosis in Imaginal Disc Cells Mol. Cell. Biol., November 1, 1999; 19(11): 7846 - 7856. [Abstract] [Full Text] [PDF]
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S. Wadd, H. Bryant, O. Filhol, J. E. Scott, T.-Y. Hsieh, R. D. Everett, and J. B. Clements The Multifunctional Herpes Simplex Virus IE63 Protein Interacts with Heterogeneous Ribonucleoprotein K and with Casein Kinase 2 J. Biol. Chem., October 8, 1999; 274(41): 28991 - 28998. [Abstract] [Full Text] [PDF]
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T. I. Meier, R. B. Peery, S. R. Jaskunas, and G. Zhao 16S rRNA Is Bound to Era of Streptococcus pneumoniae J. Bacteriol., September 1, 1999; 181(17): 5242 - 5249. [Abstract] [Full Text]
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A. N. Chkheidze, D. L. Lyakhov, A. V. Makeyev, J. Morales, J. Kong, and S. A. Liebhaber Assembly of the alpha -Globin mRNA Stability Complex Reflects Binary Interaction between the Pyrimidine-Rich 3' Untranslated Region Determinant and Poly(C) Binding Protein alpha CP Mol. Cell. Biol., July 1, 1999; 19(7): 4572 - 4581. [Abstract] [Full Text] [PDF]
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V. Lang, M. Semichon, F. Michel, C. Brossard, H. Gary-Gouy, and G. Bismuth Fyn Membrane Localization Is Necessary to Induce the Constitutive Tyrosine Phosphorylation of Sam68 in the Nucleus of T Lymphocytes J. Immunol., June 15, 1999; 162(12): 7224 - 7232. [Abstract] [Full Text] [PDF]
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D. S. Schullery, J. Ostrowski, O. N. Denisenko, L. Stempka, M. Shnyreva, H. Suzuki, M. Gschwendt, and K. Bomsztyk Regulated Interaction of Protein Kinase Cdelta with the Heterogeneous Nuclear Ribonucleoprotein K Protein J. Biol. Chem., May 21, 1999; 274(21): 15101 - 15109. [Abstract] [Full Text] [PDF]
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 J.-Y. Zhang, E. K.L. Chan, X.-X. Peng, and E. M. Tan A Novel Cytoplasmic Protein with RNA-binding Motifs Is an Autoantigen in Human Hepatocellular Carcinoma J. Exp. Med., April 5, 1999; 189(7): 1101 - 1110. [Abstract] [Full Text] [PDF]
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 M. Di Fruscio, T. Chen, and S. Richard Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis PNAS, March 16, 1999; 96(6): 2710 - 2715. [Abstract] [Full Text] [PDF]
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J. Graff, J. Cha, L. B. Blyn, and E. Ehrenfeld Interaction of Poly(rC) Binding Protein 2 with the 5' Noncoding Region of Hepatitis A Virus RNA and Its Effects on Translation J. Virol., December 1, 1998; 72(12): 9668 - 9675. [Abstract] [Full Text] [PDF]
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M. Di Fruscio, T. Chen, S. Bonyadi, P. Lasko, and S. Richard The Identification of Two Drosophila K Homology Domain Proteins. KEP1 AND SAM ARE MEMBERS OF THE Sam68 FAMILY OF GSG DOMAIN PROTEINS J. Biol. Chem., November 13, 1998; 273(46): 30122 - 30130. [Abstract] [Full Text] [PDF]
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T. Chen and S. Richard Structure-Function Analysis of Qk1: a Lethal Point Mutation in Mouse quaking Prevents Homodimerization Mol. Cell. Biol., August 1, 1998; 18(8): 4863 - 4871. [Abstract] [Full Text]
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H. Kanamori, R. E. Dodson, and D. J. Shapiro In Vitro Genetic Analysis of the RNA Binding Site of Vigilin, a Multi-KH-Domain Protein Mol. Cell. Biol., July 1, 1998; 18(7): 3991 - 4003. [Abstract] [Full Text]
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