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Nucleic Acids Research, 1993, Vol. 21, No. 7 1577-1580
© 1993

MOLECULAR BIOLOGY

A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs

Olga Bezzubova, Akira Shinohara1, Rolf G. Mueller, Hideyuki Ogawa and Jean-Marie Buerstedde*

Basel Institute for Immunology Grenzacherstrasse 487, CH-4005 Basel, Switzerland 1Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 560, Japan

* To whom correspondence should be addressed

Received January 18, 1993. Revised March 3, 1993. Accepted March 3, 1993.

Comparisons of the amino acid sequences of three yeast RecA-like proteins, Rad51 and DMC1 from S.cereviseae and Rad51 from S.pombe, revealed several highly conserved regions. Degenerated oligonucleotides encoding two of these regions were used for the polymerase chain reaction to clone a chicken RecA-like gene. The encoded protein shares 68% and 49% identical amino acids with the Rad51 and DMC1 proteins. The strong sequence conservation between the yeast and chicken genes indicates that RecA homologues are conserved throughout evolution from prokaryots to higher eukaryotes. High expression of the chicken Rad51 gene was found within the organs of lymphoid and germ cell development suggesting its involvement in lymphoid and meiotic recombination.


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