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Nucleic Acids Research, 1993, Vol. 21, No. 8 1873-1879
© 1993

MOLECULAR BIOLOGY

Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex

Andrea Caricasole and Andrew Ward*

Cancer Research Campaign Growth Factors (Zoology) Oxford, Department of Zoology, University of Oxford South Parks Road, Oxford 0X1 3PS, UK

* To whom correspondence should be addressed

Received December 22, 1992. Revised March 12, 1993. Accepted March 12, 1993.

The mouse Insulin-like growth factor II gene (Igf2) Is transcribed from three promoters (P1, P2 and P3), and Is expressed in a tissue-specific and developmentally regulated fashion; however, little information Is available on the transcription factors controlling Igf2 expression. The AP-1 complex is a transcription factor Involved In the regulation of a variety of genes, including those encoding certain growth factors. We show that Igf2 P3 Is transactlvated by AP-1 in a transient expression assay, and that this effect is mediated through two non-consensus AP-1 binding sites characterised by DNA-protein Interaction studies. Mutatlonal analysis Indicates these sites are required for AP-1 responsiveness and full promoter activity.


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