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Nucleic Acids Research, 1993, Vol. 21, No. 9 2139-2142
© 1993


MOLECULAR BIOLOGY

Timing of replication of beta satellite repeats of human chromosomes

Kelly G. Ten Hagen1 and Stanley N. Cohen1,2,*

1Departments of Genetics , Stanford University School of Medicine Stanford, CA 94305-5120, USA 2Department of Medicine, Stanford University School of Medicine Stanford, CA 94305-5120, USA

* To whom correspondence should be addressed

Received January 19, 1993. Revised March 18, 1993. Accepted March 18, 1993.

The beta satellite sequences of the human genome are a family of genetic elements consisting of 68 — 69 bp monomeric units repeated contiguously in long arrays up to 1 Mb in length. We have determined the timing of replication of beta satellite subgroups located In the heterochromatlc portion of chromosome 9 and on the acrocentric chromosomes in regions both distal and proximal to the rDNA genes. We report that these dispersed subgroups of beta satellite sequences all replicate late during S phase of the cell cycle.


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